What Are Clinical Trials And Are They Right For You
Watch a video of NIDDK Director Dr. Griffin P. Rodgers explaining the importance of participating in clinical trials.
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health. The NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.
The NIDDK would like to thank:Ariana L. Smith, M.D., FPMRS,University of Pennsylvania Health System
What Are The Signs & Symptoms Of Utis
UTIs can cause such signs as:
- pain, burning, or a stinging sensation when peeing
- an increased urge or more frequent need to pee
- waking up at night a lot to go to the bathroom
- belly pain in the area of the bladder
- foul-smelling pee that may look cloudy or contain blood
If you have any symptoms of a UTI, you’ll need to go to a doctor right away. The sooner you begin treatment, the less uncomfortable you’ll be. Call your doctor’s office or clinic. If you can’t reach your doctor, you can visit an urgent care center or hospital emergency room. The most important thing is to take action as soon as possible.
Vaccines Targeting Bacterial Toxins And Proteases
The UPEC pore-forming toxin HlyA has also received attention as a potential vaccine target and was evaluated in a mouse model of pyelonephritis to assess protection against renal damage,. Vaccination with HlyA reduced the incidence of renal scaring compared with controls however, it did not protect against UPEC colonization of the kidneys. In addition, in a mouse model of UTI, vaccination with the P. mirabilis haemolysin, HpmA, did not provide protection against bacterial colonization. However, vaccination with Pta, an alkaline protease with toxic effects towards epithelial cells, displayed promising results in a mouse model of UTI, protecting against upper UTI, although bacterial burdens in the bladder remained unaffected. Thus, although haemolysins and proteases might provide effective vaccine targets for preventing upper UTIs, additional studies are needed to determine the effectiveness of these enzymes as targets for vaccines.
Sensible Prevention For Utis
- Always wipe from front to back.
- Empty the bladder as often as possible dont hold your urine in if you can help it.
- Empty the bladder before and after sex.
- Practice good sexual hygiene by taking a shower before and after sex.
- Thoroughly wash all sex toys or other devices used during sex.
- Limit or avoid caffeine and alcohol, which can cause dehydration of your urinary tract.
- Avoid using douches, sprays or other personal care products in the vaginal area, as they can cause irritation. Products which have a fragrance are especially likely to cause irritation.
Risk Factors For Developing Utis
Some people are at greater risk than others of developing UTIs. These include:
- women sexually active women are vulnerable, in part because the urethra is only four centimetres long and bacteria have only this short distance to travel from the outside to the inside of the bladder
- people with urinary catheters such as people who are critically ill, who cant empty their own bladder
- people with diabetes changes to the immune system make a person with diabetes more vulnerable to infection
- men with prostate problems such as an enlarged prostate gland that can cause the bladder to only partially empty
- babies especially those born with physical problems of the urinary system.
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Preventing Urinary Tract Infections
There are many natural cures for urinary tract infections, but the best way to deal with a UTI is by preventing it from happening in the first place. UTIs are often preventable simply by making certain lifestyle changes:
- Wear loose clothing, such as loose pants, skirts, dresses, and cotton underwear. Since bacterium grows in moisture, tight clothing or clothing which restricts the flow of air can create the perfect breeding ground for bacteria.
- Drink plenty of water. Its good for you and helps flush bacteria from your system.
- Wipe from front to back, to stop bacteria from spreading.
- After sexual intercourse, urinate to clear out any bacteria.
If you are suffering from recurrent urinary tract infections, then there is likely something which is causing them to keep occurring. Constant medical visits and use of antibiotics may not be the answer. Simple lifestyle changes can help you stop this annoying reoccurrence. Drinking plenty of water, using natural remedies, and using proper hygiene practices can help keep UTIs away for good.
What Affects The Amount Of Urine You Produce
The amount of urine you produce depends on many factors, such as the amount of liquid and food you consume and the amount of fluid you lose through sweating and breathing. Certain medicines, medical conditions, and types of food can also affect the amount of urine you produce. Children produce less urine than adults.
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Symptoms Of A Urinary Tract Infection
Symptoms of a lower UTI include
- Pain or discomfort when urinating
- The feeling of being unable to empty your bladder fully
- Cloudy and/or foul-smelling urine that may contain blood
- Pain in your lower abdomen and pelvis
- Feeling achy, tired and generally under-the-weather
Symptoms of an upper UTI include
- A high temperature of 38°C
- Pain in your sides or back
- Shivering or chills
- Agitation or restlessness
Living With Urinary Tract Infections
If you have 3 or more urinary tract infections each year, your doctor may want you to begin a preventive antibiotic program. A small dose of an antibiotic taken every day helps to reduce the number of infections. If sexual intercourse seems to cause infections for you, your doctor many suggest taking the antibiotic after intercourse.
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What Is A Uti
Urinary tract infection is a common health problem. Between 40% and 60% of women will have at least one UTI in their lifetime. A UTI happens when bacteria from your skin or rectum get into the urinary tract. When this happens, it causes infection and inflammation. This results in symptoms such as pain with urination and needing to urinate frequently. In most cases, UTIs are easily treated with antibiotics taken by mouth.
UTIs are most common in women who have a vulva and vagina, but they can happen in women with other types of genitals as well. Every womans anatomy is unique, which means some women are more prone to infections than others.
How To Prevent Uti Re
Following some tips can help you avoid getting another UTI:
- Empty your bladder often as soon as you feel the need to pee don’t rush, and be sure you’ve emptied your bladder completely.
- Wipe from front to back after you use the toilet.
- Drink lots of water.
- Choose showers over baths.
- Stay away from feminine hygiene sprays, scented douches, and scented bath products they’ll only increase irritation.
- Cleanse your genital area before sex.
- Pee after sex to flush out any bacteria that may have entered your urethra.
- If you use a diaphragm, unlubricated condoms, or spermicidal jelly for birth control, you may want to switch to another method. Diaphragms can increase bacteria growth, while unlubricated condoms and spermicides can irritate your urinary tract. All can make UTI symptoms more likely.
- Keep your genital area dry by wearing cotton underwear and loose-fitting clothes. DonÃ¢â¬â¢t wear tight jeans and nylon underwear they can trap moisture, creating the perfect environment for bacteria growth.
Risk Factors For Urinary Tract Infections
And now a brief note about reproductive parts: Although people with penises do get UTIs, people with vaginas are more at risk. It all boils down to the anatomy, Minkin says.
Bacteria that cause UTIs often make their way from the back door to the front and then up the urethra to wreak havoc on the urinary system.
Because the male reproductive system has a longer urethra than the female reproductive system, the bacteria have farther to travel, which makes it more difficult for a UTI to develop.
But regardless of anatomy, once youve had one UTI, youre more likely to get another, especially if you have a vagina. Hickling DR, et al. . Management of recurrent urinary tract infections in healthy adult women.
Common Questions & Answers
UTI symptoms can be uncomfortable or painful. They include the following:
- A strong urge to urinate
- Pain or burning during urination
- Passing small amounts of urine
- Cloudy, strong-smelling, red or pink urine
- Mucus or discharge
- Fever, shaking, chills, or pain in the upper back, side, or groin
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How Is Dysuria Treated
Treatment for dysuria depends on the cause of your pain/burning sensation. The first step in your treatment is to determine if your painful urination is caused by infection, inflammation, dietary factors, or a problem with your bladder or prostate.
- Urinary tract infections are most commonly treated with antibiotics. If your pain is severe, you may be prescribed phenazopyridine. Note: this medication turns you urine red-orange and stains undergarments.
- Inflammation caused by irritation to the skin is usually treated by avoiding the cause of the irritant.
- Dysuria caused by an underlying bladder or prostate condition is treated by addressing the underlying condition.
There are several steps you can take to reduce the discomfort of painful urination, including drinking more water or taking an over-the-counter aid to treat painful urination. Other treatments need prescription medications.
If you have frequent urinary tract infections, your provider can help find the cause.
When To See A Healthcare Provider
If you develop signs of a kidney infection, including flank pain, nausea, or vomiting, you need to see a healthcare provider immediately.
If you are pregnant, you should never take a chance with UTIs, especially if you have diabetes, HIV, or have had previous infections. Even mild symptoms should be looked at, treated, and monitored to ensure that the infection is fully cleared.
Without exception, any symptoms of suggestive of sepsis should be treated as a medical emergency. This is especially true in babies or the elderly.
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What Are The Causes Of Kidney Infections
Normally, bacteria are flushed out by the flow of urine. However, several problems can increase the risk of a kidney infection. These problems can include:
- Structural abnormalities blocking urine flow.
- An enlarged prostate gland compressing the urethra.
- Backflow of urine from the bladder to the kidneys.
- If your immune system is affected .
- Pregnancy, during which time the enlarging uterus can squeeze the ureters and reduce the flow of urine, allowing the bacteria to migrate to the kidneys.
- Uncontrolled diabetes mellitus.
Urinary Infections In Children
A urinary infection in a child needs to be investigated as it may indicate a more serious condition.
The most common urinary system condition is urinary reflux. With this condition, the bladder valve isnt working properly and allows urine to flow back to the kidneys, increasing the risk of a kidney infection.
Urinary reflux and the associated infections can scar or permanently damage the kidney, and can also lead to:
- high blood pressure
- toxaemia in pregnancy
- kidney failure.
Urinary reflux tends to run in families, so its important to screen children as early as possible if a close relative is known to have the problem.
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Causes Of Urinary Tract Infections
UTIs are usually caused by bacteria from poo entering the urinary tract.
The bacteria enter through the tube that carries pee out of the body .
Women have a shorter urethra than men. This means bacteria are more likely to reach the bladder or kidneys and cause an infection.
Things that increase the risk of bacteria getting into the bladder include:
- having sex
do not use scented soap
do not hold your pee in if you feel the urge to go
do not rush when going for a pee try to fully empty your bladder
do not wear tight, synthetic underwear, such as nylon
do not drink lots of alcoholic drinks, as they may irritate your bladder
do not have lots of sugary food or drinks, as they may encourage bacteria to grow
Who Gets Urinary Tract Infections
Anyone can get a urinary tract infection, but they are more common in women. This is because the urethra in females is shorter and closer to the anus, where E. coli bacteria are common. Older adults also are at higher risk for developing cystitis. This increased risk may be due to incomplete emptying of the bladder. There are several medical conditions that can be related to this, including an enlarged prostate or a bladder prolapse .
If you get frequent urinary tract infections, your healthcare provider may do tests to check for other health problems such as diabetes or an abnormal urinary systemthat may be contributing to your infections. People with frequent UTIs are occasionally given low-dose antibiotics for a period of time to prevent the infection from coming back. This cautious approach to treating frequent UTIs is because your body can develop a resistance to the antibiotic and you can get other types of infections, such as C. diff colitis. This practice is used very infrequently.
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Im Pregnant How Will A Uti Affect My Baby
If you have a UTI and it isnt treated, it may lead to a kidney infection. Kidney infections may cause early labor. Fortunately, asymptomatic bacteriuria and bladder infections are usually found and treated before the kidneys become infected. If your doctor treats a urinary tract infection early and properly, it wont hurt your baby.
What If The Infection Does Not Clear Up With Treatment
Most infections clear up with treatment. However, if an infection does not clear up, or if you have repeated infections, you may be given some special tests such as:
a type of x-ray called an intravenous pyleogram , which involves injecting a dye into a vein and taking pictures of your kidney and bladder
an ultrasound exam, which gives a picture of your kidneys and bladder using sound waves
a cytoscopic exam, which uses a hollow tube with special lenses to look inside the bladder.
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What Are The Symptoms Of A Urinary Tract Infection
These are the most common symptoms of a UTI:
- Frequent urination
- Pain or burning when passing urine
- Urine looks dark, cloudy, or reddish in color
- Urine smells bad
- Feeling pain even when not urinating
- Pain in the back or side, below the ribs
- Nausea and/or vomiting
- Despite an strong urge to urinate, only a small amount of urine is passed
- Women may feel an uncomfortable pressure above the pubic bone
The symptoms of UTI may look like other conditions or medical problems. Always see a health care provider for a diagnosis.
How Do Utis Affect Pregnancy
Changes in hormone levels during pregnancy raise your risk for UTIs. UTIs during pregnancy are more likely to spread to the kidneys.
If you’re pregnant and have symptoms of a UTI, see your doctor or nurse right away. Your doctor will give you an antibiotic that is safe to take during pregnancy.
If left untreated, UTIs could lead to kidney infections and problems during pregnancy, including:
- Premature birth
- Low birth weight
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Vaccines Targeting Bacterial Adhesion
As adherence has a key role at nearly every step of UTI pathogenesis, one attractive strategy for the development of antivirulence therapies, including vaccines, has been to target CUP pili. As a general rule, vaccination with whole pili has been ineffective at generating an antibody response that can protect against UTIs. However, adhesin-based vaccines have been shown to be effective at blocking hostpathogen interactions, thus preventing the establishment of disease. Experiments using mouse and cynomolgus monkey models of UTIs determined that immunization with PapDPapG or FimCFimH chaperoneadhesin complexes protected against UTIs. The effectiveness of the FimCFimH vaccine was shown to be due, in large part, to antibodies that block the function of FimH in bladder colonization. Furthermore, the anti-FimH antibodies did not seem to alter the E. coli niche in the gut microbiota. Modifications of this vaccine are currently under development, with the aim of inducing greater immune stimulation,. For example, one approach has been to fuse FimH to the flagellin FliC in order to induce a more substantial acute inflammatory response, which functions through TLR4 signalling via the MYD88 pathway. A Phase I clinical trial began in January 2014 to evaluate the efficacy of a FimCFimH vaccine using a synthetic analogue of monophosphoryl lipid A as the adjuvant.
Symptoms Of Uti In Women
Symptoms of UTI are similar in most adults. The most common symptom of a simple UTI is called dysuria, which is pain or discomfort when you pee. You might have pain, heaviness, or a cramping feeling in your lower abdomen or pelvic area.
UTI can also cause frequency and urgency. Frequency is the need to pee more often than normal. Urgency is the feeling that you need to go right now. Occasionally, UTIs can make urine cloudy, bloody, or smell bad.
If you develop other signs and symptoms in addition to the ones above, this could mean your infection has become more serious. You should seek treatment immediately. These serious symptoms include:
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