What Medications Are Used To Treat Urinary Tract Infections

Causes Of Urinary Tract Infections

Urinary Tract Infection Nursing NCLEX | UTI Symptoms Treatment Cystitis, Pyelonephritis, Urethritis

Urinary tract infections are usually caused by bacteria from poo entering the urinary tract.

The bacteria enter through the tube that carries pee out of the body .

Women have a shorter urethra than men. This means bacteria are more likely to reach the bladder or kidneys and cause an infection.

Things that increase the risk of bacteria getting into the bladder include:

do not use scented soap
do not hold your pee in if you feel the urge to go
do not rush when going for a pee try to fully empty your bladder
do not wear tight, synthetic underwear, such as nylon
do not drink lots of alcoholic drinks, as they may irritate your bladder
do not have lots of sugary food or drinks, as they may encourage bacteria to grow
do not use condoms or a diaphragm or cap with spermicidal lube on them try non-spermicidal lube or a different type of contraception

Treatment Strategies For Recurrent Utis

Recurrent urinary tract infections, defined as three or more UTIs within 12 months, or two or more occurrences within six months, is very common among women these but arent treated exactly the same as standalone UTIs. One of the reasons: Continued intermittent courses of antibiotics are associated with allergic reactions, organ toxicities, future infection with resistant organisms, and more.

Because of this, its strongly recommended that you receive both a urinalysis and urine culture from your healthcare provider prior to initiating treatment. Once the results are in, the American Urological Association suggests that healthcare professionals do the following:

Use first-line treatments. Nitrofurantoin, TMP-SMX, and fosfomycin are the initial go-tos. However, specific drug recommendations should be dependent on the local antibiogram. An antibiogram is a periodic summary of antimicrobial susceptibilities that helps track drug resistance trends.
Repeat testing. If UTI symptoms persist after antimicrobial therapy, clinicians should repeat the urinalysis, urine culture, and antibiotic susceptibility testing to help guide further management.
Try vaginal estrogen. For peri- and post-menopausal women with recurrent UTIs, vaginal estrogen therapy is recommended to reduce risk of future UTIs.

Other Antibiotics And Treatments For Urinary Tract Infections

Other antibiotics may be as effective as first-line antibiotics but have more side effects or risks of complications. They are not commonly used. They include:

Fluoroquinolones

Antibiotics called beta-lactams may be used when other first-line antibiotics are unavailable or cannot be used for any other reason. They include:

Amoxicillin-clavulanate

These are not usually first-line choices because they are broad-spectrum antibiotics that have a higher risk of causing antibiotic resistance.

Another drug that is frequently prescribed for a UTI is phenazopyridine, available under several brand names such as Pyridium. This medication is not an antibiotic and does not cure a UTI. It is used to relieve symptoms of pain, burning, urgency and pressure.

Treatment Of Recurrent Utis

Some people develop recurring urinary tract infections and may require further testing to determine the cause. Treatment may include longer doses of antibiotics or more potent doses of antibiotics delivered intravenously. Recurrent UTIs may be a symptom of a more chronic problem and require further examination by a trained urologist.

References

Couling, R. . Managing lower UTI in adults in the community. Nurse Prescribing. 6, 485-489.

Huang, C.-H. et al. . Cranberry-Containing Products for Prevention of Urinary Tract Infections in Susceptible PopulationsA Systematic Review and Meta-analysis of Randomized Controlled Trials. Archives of Internal Medicine. 172:988-996.

OShea, L. . Diagnosing urinary tract infections. Practice Nurse. 40, 20-25.

Riley, J. . Urinary tract infection. Conditions and Procedures in Brief, 1-3.

Stapleton, A.E. et al. . Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled Trial. Mayo Clinic Proceedings. 87:143-150.

Urinary tract infection. . Mayo Clinic. Retrieved from .

Urinary tract infectionCauses. . University of Maryland Medical Center.

Urinary tract infections in adults. . National Kidney and Urologic Diseases Information. Publication No. 122097.

The FDA received at least three responses to its list ofphenazopyridine questions within a 6-month period. The ConsumerHealthcare Products Association asked the FDA to reviewphenazopyridine, but completely sidestepped the issue ofcarcinogenicity.11 A submission from PolymedicaPharmaceuticals asserted that urinarydiscomfort should be self-treatable, and further argued against warningpatients on product labels that they may need a concomitantantibacterial.12 Polymedica also claimed that phenazopyridinedosages of 190 to 195 mg are safe and effective, but did not submitclinical dosage studies to support its assertions. Polymedica arguedagainst including any carcinogenesis statement. In short, the submissionwas entirely laudatory about phenazopyridine, although it did notreport newly conducted clinical studies, as would have been required bythe FDA to establish safety and efficacy.

A brief submission from Johnson & Johnson made essentially the same arguments as Polymedica, denying theneed for carcinogenicity labeling.13 This submission also failed to include new clinical studies providing evidence of safety and efficacy.

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What Should I Know About Storage And Disposal Of This Medication

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture .

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.

Antiseptic Drug As Good As Antibiotics For Preventing Recurrent Urinary Tract Infections

And may also help tackle antibiotic resistance, say researchers

The antiseptic drug methenamine hippurate is as good as antibiotics for preventing recurrent urinary tract infections in women, finds a trial published by The BMJ today.

Its use as an alternative to antibiotics may also help tackle the global burden of antibiotic resistance, say the researchers.

Over half of women have at least one urinary tract infection in their lifetime, and recurrence occurs in about a quarter of women who have one episode.

Current guidelines recommend daily low dose antibiotics as the standard preventive treatment for recurrent UTI. But such long term use of antibiotics has been linked to antibiotic resistance, so research into non-antibiotic alternatives is urgently needed.

Methenamine hippurate is a drug that sterilises urine, stopping the growth of certain bacteria. Previous studies have shown that it could be effective in preventing UTIs, but the evidence is inconclusive and further randomised trials are needed.

So a team of UK researchers, led by clinicians and scientists from Newcastle-upon-Tyne, set out to test if methenamine hippurate is an effective alternative to standard antibiotic treatment for preventing recurrent UTI in women.

Their findings are based on 240 women with recurrent urinary tract infections requiring prophylactic treatment. On average before trial entry these women experienced over six UTI episodes per year.

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What About Antibiotic Resistance

Resistance rates for antibiotics are always variable based on local patterns in the community and specific risk factors for patients, such as recent antibiotic use, hospital stay or travel. If you have taken an antibiotic in the last 3 months or traveled internationally, be sure to tell your doctor.

High rates of antibiotic resistance are being seen with both ampicillin and amoxicillin for cystitis , although amoxicillin/clavulanate may still be an option. Other oral treatments with reported increasing rates of resistance include sulfamethoxazole and trimethoprim and the fluoroquinolones. Resistance rates for the oral cephalosporins and amoxicillin/clavulanate are still usually less than 10 percent.

Always finish taking your entire course of antibiotic unless your doctor tells you to stop. Keep taking your antibiotic even if you feel better and you think you don’t need your antibiotic anymore.

If you stop your treatment early, your infection may return quickly and you can develop resistance to the antibiotic you were using previously. Your antibiotic may not work as well the next time you use it.

Urinary Tract Infection Treatment: The Problem With Antibiotics

Urinary Tract Infection – Overview (signs and symptoms, pathophysiology, causes and treatment)

Antibiotics are drugs that are used to treat bacterial infections. However, it is completely possible for bacteria to develop resistance in response to these medicines. This makes infections more difficult to treat, leading to prolonged hospital stays, higher medical costs, and increased mortality rates.

The number of drug-resistant bacteria has been steadily increasing5 these past few years. Even when new drugs are developed, bacteria can still develop a resistance against them. This has necessitated health care providers to find non-pharmacologic methods3 like ozone therapy to use for diseases like the UTI.

Ozone gas has well-known antibacterial, antifungal, antiviral, anti-inflammatory, and analgesic effects, as well as the ability to modulate the immune system and reactivate microcirculation.

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Can A Person Get Rid Of A Uti Without Antibiotics

In some cases, the body can resolve mild, uncomplicated UTIs without antibiotics. Research suggests that 2542% of uncomplicated UTIs resolve without medical treatment.

However, not receiving treatment for a UTI does have some risks. As such, older adults, pregnant people, and those with underlying conditions should not try to treat their UTIs without antibiotics.

Treatment For Uti Symptoms

When UTI symptoms are particularly uncomfortable, a physician may also recommend phenazopyridine to alleviate the burning and discomfort to be taken in conjunction with antibiotics. This medication should not be taken for more than two days and has side effects that include headache, nausea, and changes in urine color .

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How Long Does A Uti Last

Urinary tract infections usually go away after the first few days of antibiotics treatment. Depending on the severity of the infection, they may last a bit longer. If you often get UTIs, your healthcare provider may prescribe low-dose antibiotics for a few months at a time. If you have a UTI, over-the-counter products may help ease your symptoms while you receive antibiotic treatment.

Related Resources For Utis

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This article is not medical advice. It is intended for general informational purposes and is not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.

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What Can I Do To Avoid Getting A Uti In The First Place

Women are more susceptible to U.T.I.s, as they are commonly known, owing to the way these germs infect: They often travel through fecal residue from the rectum to the urethra this can happen through sex or poor bathroom hygiene. Even taking great care does not make them entirely avoidable.

Here are some steps that can help prevent urinary tract infections: Drink plenty of fluids, which helps flush out the bladder. Empty your bladder after sexual intercourse. Practice good bathroom hygiene, which, simply put, means wiping from front to back.

During the reproductive years, women are as much as 50 times more likely than men to get a U.T.I. However, those numbers even out significantly in an aging population because men wind up getting surgical procedures, or have bowel control issues, that might lead to the same spread of germs from gut and rectum to the urinary tract.

Treatment From A Gp For Utis That Keep Coming Back

If your UTI comes back after treatment, or you have 2 UTIs in 6 months, a GP may:

prescribe a different antibiotic or prescribe a low-dose antibiotic to take for up to 6 months
prescribe a vaginal cream containing oestrogen, if you have gone through the menopause
refer you to a specialist for further tests and treatments

In some people, antibiotics do not work or urine tests do not pick up an infection, even though you have UTI symptoms.

This may mean you have a long-term UTI that is not picked up by current urine tests. Ask the GP for a referral to a specialist for further tests and treatments.

Long-term UTIs are linked to an increased risk of bladder cancer in people aged 60 and over.

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Other Health Conditions Of Concern

Keflex may not be a good choice if you have certain health conditions. Be sure to discuss your health history with your doctor before they prescribe Keflex or any other drug to treat your UTI.

Examples of conditions that could cause problems with Keflex include kidney disease and allergies to penicillin or other cephalosporins.

How Are Urinary Tract Infections Diagnosed

Urinary Tract Infections (UTI) Overview | Causes, Risk Factors, Symptoms, Diagnosis, Treatment

Your doctor will use the following tests to diagnose a urinary tract infection:

Urinalysis: This test will examine the urine for red blood cells, white blood cells and bacteria. The number of white and red blood cells found in your urine can actually indicate an infection.
Urine culture: A urine culture is used to determine the type of bacteria in your urine. This is an important test because it helps determine the appropriate treatment.

If your infection does not respond to treatment or if you keep getting infections over and over again, your doctor may use the following tests to examine your urinary tract for disease or injury:

Ultrasound: In this test, sound waves create an image of the internal organs. This test is done on top of your skin, is painless and doesnt typically need any preparation.
Cystoscopy: This test uses a special instrument fitted with a lens and a light source to see inside the bladder from the urethra.
CT scan: Another imaging test, a CT scan is a type of X-ray that takes cross sections of the body . This test is much more precise than typical X-rays.

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How To Feel Better

If your healthcare professional prescribes you antibiotics:

Take antibiotics exactly as your healthcare professional tells you.
Do not share your antibiotics with others.
Do not save antibiotics for later. Talk to your healthcare professional about safely discarding leftover antibiotics.

Drink plenty of water or other fluids. Your healthcare professional might also recommend medicine to help lessen the pain or discomfort. Talk with your healthcare professional if you have any questions about your antibiotics.

What Are Uti Symptoms

Symptoms of UTIs may include the following: pain or burning when urinating, pressure in the low belly, an urge to urinate often, and fatigue and shakiness. If you have severe pain in your back or lower abdomen, vomiting, nausea, or fever, see your healthcare provider immediately. These can be signs of a serious kidney infection. Speak with your healthcare provider if you think you may have a UTI.

Urinary Tract Infection, Centers for Disease Control and Prevention . Web. 20 September 2021.
Bladder Infection in Adults, National Institute of Health . Web. 20 September 2021.
Urinary Tract Infections, MedlinePlus. Web. 20 September 2021.
Urinary Tract Infections, Mayo Clinic. Web. 20 September 2021.
Phenazopyridine, MedlinePlus. Web. 21 September 2021.

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Does Cranberry Juice Prevent A Uti

Some patients may want to use cranberry or cranberry juice as a home remedy to treat a UTI. Cranberry juice has not been shown to cure an ongoing bacterial infection in the bladder or kidney.

Cranberry has been studied as a preventive maintenance agent for UTIs. Studies are mixed on whether cranberry can really prevent a UTI. Cranberry may work by preventing bacteria from sticking to the inside of the bladder however, it would take a large amount of cranberry juice to prevent bacterial adhesion. More recent research suggests cranberries may have no effect on preventing a UTI

According to one expert, the active ingredient in cranberries — A-type proanthocyanidins — are effective against UTI-causing bacteria, but is only in highly concentrated cranberry capsules, not in cranberry juice.
However, cranberry was not proven to prevent recurrent UTIs in several well-controlled studies, as seen in a 2012 meta-analysis of 24 trials published by the Cochrane group.
While studies are not conclusive, there is no harm in drinking cranberry juice. However, if you develop symptoms, see your doctor. Some people find large quantities of cranberry juice upsetting to the stomach.

Increasing fluid intake like water, avoiding use of spermicides, and urinating after intercourse may be helpful in preventing UTIs, although limited data is available.

How Do You Treat Utis

Urinary tract infections are usually treated with antibiotics prescribed by a healthcare provider. The length of antibiotic treatment depends on the severity of the infection, whether you have had a UTI before, and if your symptoms go away quickly. If you are prescribed antibiotics for a UTI, it is important to take them as instructed by your healthcare provider.

There are additional medications and treatments available over-the-counter that may help ease symptoms and pain or prevent additional UTIs such as urinary pain relief tablets, cranberry pills, and heating pads.