Data Synthesis And Analysis
Aggregate data from published reports were used to determine the effectof D-mannose compared to other treatments . Atminimum, two studies were required for each MA performed. Our a priori protocolhad initially planned for relative risks to be computed using a fixedeffects model where published estimates are combined using a weighted average. However, dueto the small number of studies identified for this MA, the decision was made tocompute RRs using a random effects model with robust variance estimation sinceI2 can be falsely low with a small number of studies.24 Confidence intervals forthe log RRs were determined and then exponentiated to obtain the confidenceinterval for the RR. These were computed and graphed in R, using the metafor andforestplot libraries. Two separate MAs were done: a MA of D-mannose versusplacebo, and MA of D-mannose versus antibiotics. Data are presented similarly toother SRMA with comparable primary outcomes.25
Alternative Treatments For Chronic Utis
One caveat with D-mannose is that it is only effective with UTIs caused by E. coli infection. While this accounts for about 90% of cases, there are 10% that will not benefit from this treatment. In this case, supplements that help disrupt biofilms can be useful in treating and preventing UTIs.
Biofilms are an accumulation of microorganisms and their extracellular products forming structured communities attached to a surface such as the lining of the urogenital tract. The development of a biofilm can make infections extremely hard to treat, since they commonly return shortly after treatment is stopped. The antibacterial resistance of pathogenic biofilms is one of the major reasons why those who get a UTI are highly susceptible to getting more in the future if the biofilm is not completely eliminated, the infection will eventually return at some point.
This is why the use of biofilm disruptors can be helpful for preventing the recurrence of chronic UTIs. The biofilm disruptors that I recommend to my patients are InterFase Plus from Klaire Labs or Biofilm Defense from Kirkman. These contain specialized enzymes to disrupt the biofilm matrix embedding potential of pathogens, and dissolve the sugar and fibrin components of most pathogenic biofilms. By destroying the biofilms, the recurrence of UTIs despite proper hygiene can be reduced.
Top Reviews From Other Countries
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How To Use D
The dosage used in clinical trials is around 2-3 g daily in water, ranging from 4-6 months.
There is no standardized recommendation on how much and how often to take it, but because it is deemed to be safe one could experiment a little bit with dosage and timing.
For acute UTIs, 500 mg every few hours may be a starting point.
D-mannose could be taken prophylactically at times when one is more prone to UTIs, for example just before intercourse, or generally over longer periods of time.
Abstract And Full Text Review Data Extraction And Quality Assessment
Abstracts from the systematic literature search were independentlyscreened by two authors using the stated eligibility criteria. Fulltext of selected abstracts were independently reviewed by the same two authors.Data extraction was also independently performed by two authors. In the event ofdisagreement, the two authors reviewed the study together and a third reviewerwas available if a consensus could not be made. Each of the clinicaltrials.gov search results wasreviewed to ensure that any known unpublished data were included in our MA. Atthe beginning of data extraction, an application for Prospero registration wassubmitted with our a priori protocol. Due to the extended timeline forprocessing and reviewing the application, this study was not selected to beregistered as the registry felt the study was too close to completion by thetime the application was reviewed.
We assessed the methodologic quality of each study using predefinedcriteria from a three-tier system in which studies were graded as good, fair, orpoor based on scientific merit, the likelihood of biases, and the completenessof reporting. This grading was completed according to the Cochrane Risk of Biastool and relevant questions from theNewcastle-Ottawa Scale.22,23 Selective study reportingwithin studies was assessed as part of the risk of bias assessment.
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Why Do People Take D
D-mannose is used to treat a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b.
This disease is passed down through families. It makes you lose protein through the intestines. Some reports say D-mannose slows down this protein loss and makes your liver work better. It may also reduce bleeding disorders and low blood sugar in people with this disease.
Preliminary clinical trials in Europe show that D-mannose may also treat or prevent urinary tract infections . Research suggests the supplement stops certain bacteria from sticking to the bladder walls. Scientists think that the bacteria stick to the sugar instead. This helps the bacteria leave the body through your urine. Fewer bacteria in the bladder lowers your risk of a urinary tract infection.
Some studies suggest D-mannose may play a useful role as a prebiotic. Prebiotics are substances that may help your body by stimulating the growth of good bacteria in your digestive system.
In some lab studies and studies in mice, D-mannose components were shown to increase the growth of good bacteria. This suggests D-mannose may have some use for people with dysbiosis, an imbalance in good and bad bacteria.
D-mannose supplements are taken by mouth.
Reviews & User Experiences
The opinions expressed in this section are solely those of D-mannose users who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.
Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
A lot of women take D-mannose as an alternative to antibiotics for recurrent urinary tract infections. Almost all of them reported a reduced frequency of infections, improvement of the symptoms, and absence of adverse effects. Users who rated D-mannose lower usually complained about its high price and only a few reported occasional infections despite the therapy.
Most women with active urinary tract infections were gratefully surprised to start seeing positive results after only 1-2 days, while only a few complained that the product didnt work for them.
Loose stools and bloating were the most commonly reported adverse effects.
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What To Look For
It’s important to keep in mind that dietary supplements haven’t been tested for safety and are largely unregulated in the United States.
When shopping for supplements, look for products that have been certified by ConsumerLab, The U.S. Pharmacopeial Convention, or NSF International.
These organizations don’t guarantee a product is safe or effective, but their seal indicates that a supplement has undergone testing for quality.
The Top 6 Supplements For Uti Prevention
If you have ever had a UTI, you probably want to make sure you never have another one. We have researched which urinary health products have the best science to support their use.
Our selections are the top 6 urinary tract health products, with a link to find them on Amazon.
Why we love it: This product contains many of the best-researched supplements to help prevent UTI. D-mannose, cranberry, hibiscus and dandelion are all packed together in a vegan-friendly cellulose capsule.
The product is free of gluten, soy, wheat, dairy and additives. It also contains no genetically modified organisms and is, therefore, non-GMO.
The product is made in the USA and is cGMP certified, meaning that it complies with the FDAs Good Manufacturing Processes. A single bottle contains 120 capsules. As the serving size is 2 capsules a day, the item will last 60 days. Each serving contains 1000mg of D-mannose, 150mg of cranberry juice powder from the fruit, 150mg of hibiscus flower, and 100mg of dandelion root extract. Since dandelion is related to ragweed, you may want to avoid the product if you have a ragweed allergy. Further, because hibiscus is in the mallow family with marshmallow and hollyhock, it may cause a reaction if you are allergic to those plants.
Amazon users like this product, which is a strong seller among urinary health products. Many reviewers have noted that it seems to prevent or reduce their UTIs.
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Other Applications For D
Other uses of D-mannose include reversing the effects of metabolic syndrome and support for intestinal problems.
Infants and children who have a rare inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b take D-mannose.
People with this condition have a deficiency of a specific protein in their intestines, the symptoms of which are reversible with dietary supplementation of D-mannose. In these cases, D-mannose improves liver function, lowers blood sugar levels, and helps prevent blood clotting disorders.
Some studies show that D-mannose may act as a prebiotic and may therefore help regulate the gut microbiome.
A prebiotic is a food substance that is non-digestible to humans, but provides a food source for good bacteria in your digestive system.
Uti Treatment Without Antibiotics
UTIs can be at best uncomfortable but can become dangerous if left untreated. Since they are so common, doctors are generally quick to treat them with antibiotics, which unfortunately can cause side effects such as diarrhea, yeast infections, and nausea, not to mention killing off many beneficial bacteria in the process. If you have a UTI, these side effects may leave you looking for an alternative treatment to try first, instead of automatically going the antibiotic route. As always, it is best to talk to your doctor before trying any treatments since untreated UTIs can be quite serious and lead to permanent kidney damage.
D-mannose has proven effective for recurrent UTIs in several studies. A 2013 study published in the World Journal of Urology compared the use of antibiotics and D-mannose in 308 women with a history of recurrent UTI. The participants of the study were divided into three groups, the first received 2g of D-mannose for 6 months, the second a common antibiotic used to treat UTIs, and the third did not receive any treatment. In the group that received the D-mannose only 14% continued to have recurrent UTIs, whereas 20% continued in the antibiotic group, and 62% in the placebo group. Those in the D-mannose group also reported significantly fewer side effects than those on antibiotics. The researchers determined that based on these results the D-mannose was equally as effective as the antibiotics.
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What Are The Possible Side Effects Of Using D
D-mannose is generally well tolerated by children and adults. However, there have been no studies done to confirm whether D-mannose is safe during pregnancy or breastfeeding.
Manufacturers of D-mannose state that possible side effects include bloating and loose stools.
In addition to the lack of general knowledge about D-mannose on its own, how D-mannose may interact with other medications and supplements is not well studied. Its always best to talk to your doctor if you are concerned.
The Top 6 Supplements For Urinary Tract Health
Bladder health is easy to take for granted. That is, until you get a tell-tale pain or discomfort in the pelvis. This kind of pain may mean that you have a urinary tract infection, or UTI. Luckily, UTIs can be treated with antibiotics.
However, especially if you suffer from recurrent UTI, it can be painful, frustrating and disheartening to get infections on a regular basis.
Although antibiotics are the only way to get rid of a UTI once it has started, several different supplements can help to prevent UTIs from happening in the first place. For this reason, we have scoured the internet to find the top 6 best supplements for urinary health.
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Information Sources And Search Strategy
A comprehensive literature search was performed with a medical librarianusing search strategies, standardized terms, and keywords for the concepts ofrecurrent urinary tract infection and mannose. These strategies were executed inOvid Medline 1946-, Embase 1947-, Scopus 1823-, Cochrane Library, Web of Science1900-, and Clinicaltrials.gov. All searches werecompleted on February 5, 2018, March 5, 2019, and again on April 15, 2020.Database-supplied English language limits were applied. Endnote was used fordeduplication. Manual checks and comparisons were also performed to determinewhether abstracts were unique or duplicates. If there was any uncertainty at theabstract level, the two authors reviewed the full-text article and came toconsensus. The full search strategies can be found in the appendix and they followed a similar strategy as theone used for Ovid-Medline April 2020 search: or or bacteriuria or pyuria or schistosomiasishaematobia or cystalgia or cystitis or pyelocystitis or exp cystitis/or AND .
Customer Questions & Answers
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Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we donât use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
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Can I Eat Enough Cranberries To Get An Active Dosage Of D
Another source of D-mannose is cranberries. However, D-mannose makes up just 0.04% of the dry weight of cranberries. This is quite low in comparison to other sources, even the spent coffee grounds.
Needless to say, you would need to eat a ton of cranberries for your body to gain anything close to a protective dose of D-mannose. So this is not recommended as a method of ingesting D-mannose.
Watch our expert video series to learn more about D-mannose for UTI.
So Why Doesnt My Doctor Know About D
Many physicians must follow official treatment guidelines from the FDA. Otherwise, they risk litigation and negligence suits.
Second, as D-Mannose is a natural substance that is not well regulated, there is a significant variation in the quality of supplements, making it difficult to predict how well it will work.
Third, no large clinical trials evaluate D-Mannose as that would require significant financial investment form pharmaceutical companies that would not be profitable. .
Its ironic, though, that many physicians recommend cranberry supplements for UTI, which have not equivocally been proven to treat UTIs, while so few are aware of D-Mannose.
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Treatment From A Gp For Utis That Keep Coming Back
If your UTI comes back after treatment, you may have a urine test and be prescribed different antibiotics.
Your doctor or nurse will also offer advice on how to prevent UTIs.
If you keep getting UTIs and regularly need treatment, a GP may give you a repeat prescription for antibiotics.
If you have been through the menopause, you may be offered a vaginal cream containing oestrogen.
Why Is There A Link Between D
While many bacteria can cause a UTI, the most common pathogen for both uncomplicated and complicated UTI is gram-negative uro-pathogenic Escherichia coli or UPEC. UPEC are responsible for 80%90% of all uncomplicated UTI and approximately 65% of complicated UTIs.1
Most E-coli strains live harmlessly in the the gut of humans and animals such as cattle, pigs, sheep and poultry. Strains of E-coli, as part of the gut flora, play a part in the digestive process.
UPEC can be shed in your stools, allowing them to live on the perineum or the urogenital area . This can lead to bacteria being introduced into the urinary tract.
Upon entering the bladder, these infection causing bacteria must ensure they are able to bind to the bladder lining and/or a surface such as a catheter to establish and develop a bacterial colony. To do this, UPEC species change shape and develop adhesive pili on their surface. These are known as Type 1 FimH and it is these that allow these bacteria to stick and thus begin to establish colonies. Think of them as grappling hooks. During bacterial colonization, these grappling hooks bind to carbohydratecontaining protein receptors found in the cells of the bladder wall and effective bacterial colonies can develop as these receptors provide the right nutrients for growth.
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How To Make Sure You Choose The Right D Mannose For Uti
If you are an early or new user, it might be difficult for you to find the proper d mannose for uti. You might be unaware of certain facets of the d mannose for uti that you might have been thinking about. But we are here to help you out with that! The recommendations below might be helpful in your chase: