About Oab And Detrusor Overactivity
OAB and detrusor overactivity can both cause trouble with urination. With these conditions, you may have involuntary spasms in your bladder muscles, even when you dont actually need to urinate.
The exact cause of OAB isnt known. But some possible factors or causes may include:
- consuming caffeine, alcohol, or other bladder irritants
- taking medications that increase urine output
- other bladder problems, such as bladder stones
- not completely emptying the bladder
Detrusor overactivity can be linked with neurological conditions such as MS or a spinal cord injury. These neurological conditions affect how your brain communicates with the rest of your body. In some cases, they can cause bladder problems such as detrusor overactivity.
Botox As Incontinence Therapy
A minimal Botox procedure can provide dramatic results for older adults who experience urinary incontinence.
For the large percentage of older Americans who struggle with urinary incontinence, a growing body of research suggests that Botox is a therapy worthy of serious consideration.1-5
Close to one-half of Americans over the age of 65 who live at home struggle with urinary incontinence, and the figures are substantially higher for older adults who are institutionalized: Fully 75% of long-term nursing home residents lack complete bladder control. Both genders are susceptible, though the condition disproportionately affects women.6
A study presented at the American Urological Association annual meeting in June 2015, however, found that Botox is a highly effective treatment, with approximately 80% of patients reporting being “improved” or “greatly improved” following treatment.5 According to Victor Nitti, MD, a professor of urology and obstetrics/gynecology at New York University Langone Medical Center and one of the researchers involved in the study, the success rate in the study is similar to that reported previously in other studies and in clinical practice.
“The improvement is often much more dramatic than the types of improvement seen with medication,” Nitti says. “That’s not to say that you can’t have somebody who starts on an oral medication and has a phenomenal response,” but the likelihood is lower, he says.
What To Expect With Botox For Migraine
For migraine management, youll typically receive Botox injections once every 3 months. During your injection visits, your doctor will give you multiple injections of the drug. Theyll typically inject Botox into muscles in the following areas:
- your forehead
- the area around your temples
- the back of your neck
Botox can help reduce the number of migraine attacks you have and how long they last. But the drug wont completely stop your migraine headaches. In addition, Botox doesnt work right away, and it doesnt work for everyone.
Some people start to see an improvement in their migraine headaches just 2 to 4 weeks after their first set of Botox injections. But it can take two sets of injections and up to 6 months of treatment before you get the maximum effect from Botox.
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Effectiveness For Chronic Migraine
In two clinical studies, Botox was effective in preventing migraine headaches. In these studies, adults with chronic migraine received either Botox or a placebo . Treatment was administered as two sets of injections, which were each given 3 months apart.
After 6 months of treatment:
- people who were given Botox had an average of 7.8 to 9.2 fewer migraine days per month than they had before treatment
- people who were given the placebo had an average of 6.4 to 6.9 fewer migraine days per month than they had before treatment
The study also showed that, on average:
- people who were given Botox had 107 to 134 fewer hours of headache per month
- people who were given the placebo had 70 to 95 fewer hours of headache per month
Are There Any Long
In general, you may have side effects within the first week of receiving Botox injections. Most of the time, these side effects are temporary, but sometimes, side effects can last for several months or longer.
But possible long-term side effects of Botox can include:
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What To Expect After A Botox Injection In The Bladder
After your doctor finishes administering Botox in your bladder, they will monitor you in the office for about 30 minutes. You will be asked to empty your bladder before leaving the office and your doctor will check that no extra urine is retained when you use the restroom. Your doctor may prescribe 1-3 days of antibiotic pills to make sure you dont get an infection.
Do You Need Anesthesia For Bladder Botox Injections
Botox bladder injections are performed as an outpatient procedure. You do not need general anesthesia for Botox injections in the bladder, but your doctor will administer a local anesthetic to temporarily numb your bladder so you will not feel the injections, similar to how a dentist numbs your mouth before filling a cavity. The local anesthetic generally wears off within one hour of completing the injections. Because Botox bladder injections do not require general anesthesia, you can drive yourself to and from your treatment.
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Is Botox Safe For Older People To Use
Yes, in general, Botox is safe for use in older people. In clinical studies, there werent any differences in the overall safety of the drug between older people and younger people.
However, in people who used Botox for overactive bladder ,* certain side effects were more common in older people than in younger people. These side effects were urinary tract infections and trouble emptying the bladder.
If you have questions about the safety of using Botox given your age, talk with your doctor.
* To learn about OAB, see the Other uses for Botox section above.
How Long Does It Take For Botox To Work
Botox starts to have its effect on nerve endings in your body within 24 to 72 hours after its injected. But it typically takes up to 2 weeks before the drug has its full effect and you notice a difference in your symptoms. However, for some people, it can take longer than 2 weeks for this to occur.
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What Is The Most Important Information I Should Know About Botox
You should not be treated with Botox if you are allergic to botulinum toxin, or if you have:
- an infection in the area where the medicine will be injected or
- if you have a current bladder infection or if you are unable to urinate and you do not routinely use a catheter.
Tell your doctor if you have ever had:
- other botulinum toxin injections such as Dysport or Myobloc
- amyotrophic lateral sclerosis
- myasthenia gravis
Why Choose The University Of Maryland Medical Center
The University of Maryland’s Center for Continence and Pelvic Health is a one stop-shop for patients with urinary incontinence. Our physicians have the training and expertise necessary to provide the most advanced care available for women with problems related to the lower urinary tract or pelvic floor. Our team of gynecologists and urologists work together to provide patients with the best evidence-based medicine to treat urinary incontinence.
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Dosage For Chronic Migraine
The recommended dosage of Botox for chronic migraine is 155 units. This total dose is given as 31 injections of 5 units each. The injections are given into recommended injection sites, which are described in the How Botox is given section above.
Botox treatment for chronic migraine is typically repeated once every 12 weeks.
Note: To learn more about chronic migraine, see the Botox for chronic migraine section above.
Botox For Overactive Bladder Urgency Incontinence And Neurogenic Lower Urinary Tract Dysfunction:
Botox injection into the bladder is a well-established treatment for overactive bladder and urgency incontinence, including urgency incontinence associated with neurological disease. It is usually used when behavioral and exercise therapies and medications have not been effective in treating symptoms. Botox has been shown to produce dramatic improvements in symptoms and quality of life in women who have not responded to or could not tolerated other treatments. At the Center for Women’s Pelvic Health at UCLA, our physicians did some of the pioneering work on use of Botox for overactive bladder and incontinence over the past 15 years. In most cases Botox can be done in an office setting with local anesthesia instilled into the bladder.
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Botox Treatment For Urinary Incontinence
In the 1980s, Botox® was developed and approved by the FDA for the treatment of certain eye muscle disorders. Shortly thereafter, Botox gained acclaim as a cosmetic product to treat wrinkles. Since the late 1990s, it has been used to treat disorders of the bladder, primarily overactive bladder. Doctors typically try to treat incontinence with medication before using Botox, but Botox is an extremely effective treatment for bladder leakage.
Botox Bladder Injections For Incontinence What To Know
Urinary incontinence is a condition where the urinary sphincter is weakened, causing involuntary urine leakage. There are two types of incontinence, including urge incontinence, which is caused by your bladder contracting and stress incontinence, which is caused by physical activity or movement.
Both can happen at the same time and cause irritability. They may also impair social and physical well-being.
There are several ways you can treat urinary incontinence, and one is through Botox injections. Botox is not only used to treat wrinkles in the face but also to relieve and address bladder continence issues.
When you inject Botox for the bladder, the drug helps block certain nerves from communicating with the sphincter muscles or the bladder itself, relieving certain bladder symptoms such as the inability to delay urination. However, it takes about a week before the drug fully works in the system.
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Side Effects In Children
Botox is approved for use in children with certain conditions. Below, we list these conditions and briefly describe the side effects seen in children who have them.
- Upper and lower limb spasticity . The most common side effect in children with these conditions is upper respiratory tract infection, such as the common cold. This side effect occurs more often in children with these conditions than it does in adults.
- Blepharospasm and strabismus . Side effects of Botox in children with these conditions are similar to side effects in adults treated for these conditions.
Will I Have Side Effects If I Stop Using Botox
Stopping Botox treatment doesnt cause unique side effects. But as the amount of the drug in your body decreases, symptoms of the condition you were using Botox to treat may develop.
Botoxs effects usually wear off by about 12 weeks after your last dose. Sometimes this can result in your condition coming back. For example, chronic migraine headaches may get worse than they were prior to Botox treatment after you stop the drug.
If you have questions about stopping Botox, talk with your doctor. They can discuss how stopping treatment may affect your condition.
Learn more about some of the side effects that Botox may cause.
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What Are The Side Effects Of Botox
The lists below include some of the main side effects that have been reported in people using Botox. For information about other possible side effects of the drug, talk with your doctor or pharmacist.
You can also learn more about side effects from this in-depth Botox article or from the drugs medication guide.
Note: After the Food and Drug Administration approves a drug, it tracks and reviews side effects of the medication. If youd like to notify the FDA about a side effect youve had with Botox, visit MedWatch.
What To Expect After Botox Injection In Bladder
If youve ever gone for a jog and felt a trickle down below, or coughed and caught yourself leaking urine, you arent alone. The involuntary loss of urine is called urinary incontinence and more than 25 million Americans experience it Read More
If youve ever gone for a jog and felt a trickle down below, or coughed and caught yourself leaking urine, you arent alone. The involuntary loss of urine is called urinary incontinence and more than 25 million Americans experience it every day. Urinary incontinence can be caused by several factors from a urinary tract infection to overactive bladder to pregnancy and childbirth. The good news is urinary incontinence is a treatable medical condition, with one of the most effective treatments being Botox.
When most people think of Botox, they usually think of injections to the face to minimize wrinkles. However, Botox bladder injections are a routine treatment for urinary incontinence.
Here is a guide to what you should know about Botox injections in the bladder.
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How Does Botox Treat Urinary Incontinence
Botox has been used to treat urinary incontinence for many years. It acts to decrease the muscular contractions of the bladder. These bladder spasms can arise from routine overactive bladder, which commonly occurs in women with aging or they can be more serious in patients with neurogenic bladder from neurologic disease or injury.
Bladder spasticity has a lot of different names it is also called overactive bladder, detrusor overactivity, detrusor hyperreflexia, and neurogenic bladder.
Dosage For Upper And Lower Limb Spasticity
The typical dosage of Botox for upper limb spasticity in adults ranges from 75 units to 400 units. For lower limb spasticity in adults, the typical dosage of Botox ranges from 300 units to 400 units. Dosages for limb spasticity in children are described below in the Pediatric dosage section.
The exact Botox dosage for this use depends on the size, location, and number of muscles affected. It also depends on the severity of your spasticity. The total recommended dosage for spasticity is divided into multiple injections into affected muscles.
Botox treatment for spasticity may be repeated when the drugs effect wears off. But each treatment session must be at least 12 weeks apart.
The dosage youre given for spasticity may change each time you have a session for Botox injections. Your dosage will vary depending on how your body responded to previous injections.
Note: To learn more about upper and lower limb spasticity, see the Other uses for Botox section above.
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What Is Botox And How Does It Work
Botox® is a pharmaceutical preparation of the botulinum toxin type A produced by the bacterium Clostridium botulinum, which has muscle relaxant properties. It is usually used in MS for two reasons.
The first reason is for the relief of focal muscle spasticity and is usually used in conjunction with stretching and physiotherapy.
The second reason Botox is helpful in MS, is for the treatment of urinary incontinence due to overactivity of the detrusor muscle in the bladder. There are strict criteria to guide selection of the most suitable patients for this procedure, where clinical trials have shown significant improvements in quality of life and incontinence episodes.
Drug Forms And Strengths
Botox comes as a powder inside single-use vials. Its mixed with liquid to form a solution thats given as an injection. Youll receive Botox injections from a healthcare provider.
For most of its uses, Botox is given by intramuscular injection . Its injected into muscles in different areas of your body, depending on the condition being treated.
For OAB and urinary incontinence caused by a nerve disorder, Botox is injected into the detrusor muscle of the bladder. This injection is done using a thin tube called a cystoscope thats inserted into your bladder.
And for excessive sweating, Botox is injected into the skin of your armpit.
Botox is available in two strengths: 100 units and 200 units.
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But Both Have Side Effects That May Affect Your Choice Researchers Say
TUESDAY, Oct. 4, 2016 — For women with bladder incontinence who haven’t been helped by medications or other therapies, Botox injections may help control leakage better than an implanted nerve stimulation device, a new study suggests.
However, both treatments are effective, according to doctors who treat the condition.
In a head-to-head comparison, women given Botox saw their number of daily urgency incontinent episodes decrease by four, on average, compared to three for women who received the implant, called InterStim.
Botox patients also said they had a greater reduction in symptoms and were more satisfied with the treatment, the researchers said.
“Many women suffer from urgency incontinence and find inadequate relief of their problem from medications or behavioral changes,” said lead researcher Dr. Cindy Amundsen. She’s a professor of obstetrics and gynecology at Duke University in Durham, N.C.
“Both therapies appear to be very good options for women,” Amundsen said. The differences in effectiveness between Botox and InterStim were small, but statistically significant, she added.
Urgency incontinence causes a strong, sudden need to urinate, according to the U.S. National Institutes of Health. The condition is also called overactive bladder. Urgency incontinence is common. The problem affects about 17 percent of women over 45, and 27 percent of women over 75, the study authors noted.
“These side effects didn’t really influence how patients thought about Botox,” she said.
Financial And Insurance Assistance
If you need financial support to pay for Botox, or if you need help understanding your insurance coverage, help is available.
Allergan, the manufacturer of Botox, offers the Botox Savings Program, which may help lower the cost of your treatment. For more information and to find out if youre eligible for support, call 800-44-BOTOX or visit the program website.
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