Tuesday, October 4, 2022

Can Humira Cause Urinary Tract Infections

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How Your Digestion Can Contribute To A Uti Or Aerobic Vaginitis

Adalimumab (Humira) – IBD treatments explained by the experts

The urinary tract has its own microbial ecosystem, which in women resembles vaginal flora. This means that a healthy vagina supports a healthy urinary tract.

If you have digestive problems, the gut microbiome can become unhealthy, contributing to poor vaginal health due to proximity of the anus to the vagina.

Poor digestive health typically results in unbalanced gut flora, where pathogens are able to proliferate because of the absence or lack of healthy intestinal flora. E. coli naturally resides in the colon, and can overgrow, resulting in more frequent cross-contamination with the vagina and urinary tract. This highlights the importance of focusing on gut health when dealing with frequent vulvovaginal or urinary tract infections.

Constipation, for example, leaves stool in the colon for long periods of time, providing an ongoing food source for microbes. Having a healthy bowel movement every day at least once ensures that the microbial colonies in the digestive tract are kept in check, since the stool passing through acts like a broom.

Fibre makes stools larger and firmer, creating a sort of boulder that moves through the intestines, picking up anything in its way and pushing it out.

Diarrhoea doesnt have the same effect as constipation, but comes with its own issues think of wet sand in a wet sock. Bits of faeces can remain on the intestine walls, being slow to move through. This too provides a lingering food source for microbes.

What Is The Most Important Information I Should Know About Humira

You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a tumor necrosis factor blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.

  • Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA. If your doctor feels you are at risk, you may be treated with medicine for TB.
  • Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer may increase. These types are generally not life-threatening if treated tell your doctor if you have a bump or open sore that doesnt heal.

Dosage For Ulcerative Colitis

The usual dosage of Stelara for adults with ulcerative colitis is 90 mg given once every 8 weeks. Stelara is given as a subcutaneous injection. When treating ulcerative colitis, this is called your maintenance dose.

However, the first dose of Stelara that youll receive is called an induction dose. Its given as an intravenous infusion . This infusion lasts at least 1 hour.

The usual dosage for the loading dose is based on your body weight, as follows:

  • for adults who weigh 55 kilograms or less, the loading dose is 260 mg
  • for adults who weigh between 55 kilograms and 85 kilograms , the loading dose is 390 mg
  • for adults who weigh more than 85 kilograms, the loading dose is 520 mg

Every dose of Stelara that you receive after your loading dose will be given as a subcutaneous injection.

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Typical Dosing For Humira

  • Adults: Humira is injected under the skin. The dose and dosing schedule will depend on the condition being treated, but the typical dose is generally 40 mg or 80 mg every other week. For some conditions like Crohn’s disease, ulcerative colitis, and hidradenitis suppurativa, a starting dose of 160 mg is given on the first day, a second dose of 80 mg after two weeks, then a regular every-other-week schedule begins.

  • Children: Humira is injected under the skin. The dose will be based on your child’s weight. The dosing schedule will depend on the condition being treated, but it will generally be given once a week or every other week.

What To Do In Case You Take Too Much Humira

Vanessa TEICH

If youve injected too much Humira, talk to your doctor immediately. They may want to monitor you for signs and symptoms of overdose.

You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. But if you have severe symptoms, immediately call 911 or go to the nearest emergency room.

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Drug Forms And Strengths

Stelara comes as a liquid solution that contains the active drug ustekinumab.

Its available as:

  • a single-dose, prefilled syringe that holds 0.5 mL of solution and contains 45 mg of ustekinumab
  • a single-dose, prefilled syringe that holds 1 mL of solution and contains 90 mg of ustekinumab
  • a single-dose vial that holds 0.5 mL of solution and contains 45 mg of ustekinumab

Stelara is given as a subcutaneous injection. It can be given in your upper arms, thighs, belly, or buttocks.

Your healthcare professional may give you Stelara injections at a medical clinic. They may also show you how to self-inject Stelara at home.

Note: Stelara also comes in a vial that contains 130 mg of ustekinumab. This vial is used for a one-time intravenous infusion of Stelara. Its used to give the first dose of the drug to people with Crohns disease or ulcerative colitis. This one-time infusion is called a loading dose or an induction dose. This IV infusion will take place over at least 1 hour. Each dose of Stelara after the IV infusion is given as a subcutaneous injection.

Dosage For Psoriatic Arthritis

The usual dose of Stelara for adults with psoriatic arthritis is 45 mg for each injection.

Stelara is given as one subcutaneous injection on each of the following days:

  • your first dose is given on day 1
  • your second dose is given 4 weeks later
  • your third dose is given 12 weeks after your second dose
  • the rest of your doses are given every 12 weeks

If you have psoriatic arthritis with plaque psoriasis, your doctor may prescribe a higher dosage of Stelara for you.

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Side Effects After First Dose Of Humira

Its possible to have side effects after your first dose of Humira, such as injection site reactions. These reactions may include itching, pain, or swelling in the area of your Humira injection. Its also possible to experience other side effects, including serious side effects, after your first dose.

Depending on the condition youre taking Humira to treat, you may take the drug every week or every other week. Its possible to experience side effects after these other doses, as well.

If you have questions about what to expect after your first dose of Humira, talk with your doctor or pharmacist.

Information You Should Share With Your Doctor Before Starting Humira

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Tell your doctor if you have, or have had, any of the following:

  • an infection, including a long-term infection in one part of the body
  • infections which keep coming back or other conditions that increase the risk of infections
  • you are a carrier of the hepatitis B virus or you have active HBV or you think you might be at risk of contracting HBV
  • tuberculosis, or if you have been in close contact with someone who has had tuberculosis
  • a fungal infection
  • cancer or autoimmune disease
  • a lung disease called chronic obstructive pulmonary disease
  • you have or develop a demyelinating disease
  • a serious heart condition
  • you experience allergic reactions such as chest tightness, wheezing, dizziness, swelling or rash
  • low resistance to disease
  • uveitis. Your doctor may check for signs and symptoms of neurologic disease before starting thismedicine.

As cases of tuberculosis have been reported in people treated with HUMIRA, your doctor will check you for signs and symptoms of tuberculosis before starting treatment. This will include a thorough medical examination, including your medical history and appropriate screening tests .

HUMIRA can cause reactivation of hepatitis B in people who carry this virus. In some rare cases, especially if you are taking other medicines that suppress the immune system, reactivation of hepatitis B virus can be life-threatening.

Tell your doctor if you have psoriasis and have undergone phototherapy, also known as light therapy.

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Stelara And Other Medications Or Therapies

Below are lists of medications and therapies that can interact with Stelara. These lists do not contain all the drugs that may interact with Stelara.

Before taking Stelara, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Stelara and vaccines

You shouldnt get a live vaccine when youre using Stelara. Getting a live vaccine during Stelara treatment increases your risk of getting the condition the vaccine is meant to prevent.

This is because Stelara suppresses your immune systems ability to fight infections. Receiving a live vaccine during Stelara treatment increases your risk of serious infections.

Examples of live vaccines that you should avoid during Stelara treatment include:

You should also avoid getting the Bacillus Calmette-Guérin vaccine for 1 year before you start using Stelara, during your Stelara treatment, and for 1 year after you stop using Stelara. The BCG vaccine is meant to prevent tuberculosis . Its more commonly given to people who live outside of the United States.

Stelara and allergy shots

Stelara and warfarin

If youre taking these drugs together, your doctor may need to adjust your dosage of either Stelara or warfarin.

  • everolimus
  • sirolimus

What If I Miss A Dose

Its important to keep your appointments with your healthcare professional for Stelara injections. If you miss an appointment, call your doctors office right away. They can reschedule your appointment.

If youre using Stelara at home and you miss a dose, take it as soon as you remember. Dont take more than one dose at a time. This can increase your risk of serious side effects.

Talk with your doctor about any missed doses. They can help you set up a new schedule for your Stelara treatment.

To help make sure that you dont miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

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Warning Disclaimer Use For Publication

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Side Effects Not Requiring Immediate Medical Attention

Inflammatory Bowel Disease Causes, Symptoms And Treatment ...

Some side effects of adalimumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bladder pain
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • pounding in the ears

Applies to adalimumab: subcutaneous kit, subcutaneous solution

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Suggest Treatment For Frequent Urination And Presence Of Blood In Urinary

My husband is urinating blood and having to make frequent trips to bathroom. And. Leaking before he gets to bathroom. What could the problem be ? View answer

All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions

Consumer Information Use And Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care providers examination and assessment of a patients specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at .

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Stelara For Crohns Disease

Stelara is FDA-approved to treat moderate to severe Crohns disease in adults.

Crohns disease is a type of inflammatory bowel disease. It causes inflammation in your gastrointestinal tract.

With Crohns disease, you may have:

  • diarrhea
  • pain and cramps in your belly

Effectiveness for Crohns disease

One clinical study looked at effectiveness after 8 weeks of treatment. In this study, clinical remission was reached in 14% to 21% more people who took Stelara than in those who took a placebo .

Clinical remission can also be defined based on a scoring system that measures how severe peoples Crohns disease symptoms are. Lower scores show fewer Crohns disease symptoms. If you have a score of less than 150 points, youre considered to be in remission. The highest possible score is 1,100.

In these 8-week studies, between 18% and 26% more people taking Stelara than those taking the placebo had a decreased score of at least 100 points.

Does Humira Cause Weight Gain Or Weight Loss

IBD School 226: Fistulas

No, Humira doesnt cause weight gain or weight loss. But if you get a serious infection during Humira treatment, you might lose weight. And serious infections are a possible side effect of this drug.

If you have unexplained weight gain or weight loss when using Humira, tell your doctor. They can check to see what might be causing your weight change.

If youre concerned about any other weight changes while youre taking Humira, talk with your doctor. They can provide tips to help you manage a body weight thats healthy for you.

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What Will Happen If I Stop Taking Humira Will I Have Withdrawal Symptoms

If you stop taking Humira, the symptoms of your condition may come back. But you wont have withdrawal symptoms from the medication itself.

If you need to stop taking Humira, your doctor will closely monitor you for symptoms of your condition. If your symptoms return, your doctor may recommend that you restart treatment with Humira. Or they may suggest another drug to manage your condition.

Financial And Insurance Assistance

If you need financial support to pay for Stelara, or if you need help understanding your insurance coverage, help is available.

Janssen Biotech, Inc., the manufacturer of Stelara, offers a program called Janssen CarePath. For more information and to find out if youre eligible for support, call 877-CAREPATH or visit the program website.

Your doctor will recommend if you need to take other drugs with Stelara to treat your condition.

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Side Effects In Children

In a clinical study, children ages 12 years and older with plaque psoriasis used Stelara for treatment. The side effects in these children were similar to the side effects in adults with plaque psoriasis during other clinical studies.

The Stelara dosage your doctor prescribes will depend on several factors. These include:

  • the condition, or conditions, youre using Stelara to treat
  • your age
  • your weight

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Is Humira An Immunosuppressant

Bactrim and Humira drug interactions, a phase IV clinical ...

Yes, Humira is an immunosuppressant drug.

It blocks the action of a protein made by your immune system called tumor necrosis factor . TNF is an important protein that helps your body fight off infections.

Its thought that excessive amounts of TNF are responsible for causing inflammation that leads to many diseases. These diseases include rheumatoid arthritis and plaque psoriasis, both of which Humira treats.

But by blocking TNF, Humira lowers the activity of your immune system. And this can put you at risk for infections, including serious infections. This is one of the for Humira.

If you have more questions about Humiras effect on your immune system, talk with your doctor.

Humira and Enbrel have similar uses, but they also have some differences. To see a side-by-side comparison of these two drugs, check out this article.

Read below to learn about Humira and other alternative drugs.

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